Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.3K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.3K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

40.8K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
40.8K
Understanding Sleep01:11

Understanding Sleep

1.2K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.2K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

217
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
217
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

779
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
779
The Pineal Gland01:02

The Pineal Gland

3.5K
The pineal gland, a diminutive endocrine structure named for its pinecone-shaped appearance, is situated atop the third ventricle within the diencephalon region of the forebrain. This gland, composed of secretory cells known as pinealocytes arranged in compact cords and clusters around dense particles of calcium salts, plays a pivotal role in hormonal regulation.
The primary secretion of the pineal gland is the hormone melatonin, derived from serotonin. The concentration of melatonin in the...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First-in-Human Safety and Feasibility of Nodal and Pedal MR Lymphangiography with Gadopiclenol.

Radiology. Cardiothoracic imaging·2026
Same author

Novel adult learning-based curriculum for pathology residents: components and critique at five years.

Academic pathology·2026
Same author

Controlling Spatio-Temporal Sequences of Neural Activity by Local Synaptic Changes.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Divergent behavioral strategies in Wistar and Wistar-Kyoto rats in a naturalistic task reveal mood disorder phenotypes.

iScience·2026
Same author

The effects of chronic cannabidiol administration on brain pathology and behavioral deficits found in the tau P301s-line PS19 mouse model of Alzheimer's disease.

Journal of Alzheimer's disease : JAD·2026
Same author

Robust input disentanglement through dendritic calcium-mediated action potentials.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Dissecting first-episode psychosis heterogeneity with clustering analyses: a systematic review.

Neuroscience and biobehavioral reviews·2026
Same journal

Irisin and anxiety-like behaviors: Mechanistic integration of peripheral-central crosstalk, neuroinflammation and neural plasticity.

Neuroscience and biobehavioral reviews·2026
Same journal

Efficacy of Non-Invasive Brain Stimulation in Alzheimer's Disease: An Umbrella Review of Meta-Analyses.

Neuroscience and biobehavioral reviews·2026
Same journal

Rhythms of interaction - the timescales of social coordination and why they matter.

Neuroscience and biobehavioral reviews·2026
Same journal

Neural Bases of Memory Development: Insights from Magnetic Resonance Imaging.

Neuroscience and biobehavioral reviews·2026
Same journal

Regional heterogeneity of brain insulin resistance: From molecular pathways to neural circuits.

Neuroscience and biobehavioral reviews·2026
See all related articles

Related Experiment Video

Updated: Nov 20, 2025

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

13.1K

A local circadian clock for memory?

Andrew B Lehr1, Robert J McDonald2, Christina M Thorpe3

  • 1Department of Computational Neuroscience, University of Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, Germany.

Neuroscience and Biobehavioral Reviews
|January 21, 2021
PubMed
Summary
This summary is machine-generated.

A novel theoretical framework suggests the hippocampus has an independent circadian clock influencing memory. This local clock mechanism could improve memory and lead to new therapies for circadian rhythm disruption.

Keywords:
Circadian rhythmsHippocampusLearning and memoryPeripheral oscillatorSCNSemi-autonomous

More Related Videos

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.5K
Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture
07:05

Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture

Published on: January 19, 2018

7.8K

Related Experiment Videos

Last Updated: Nov 20, 2025

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
07:42

Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter

Published on: September 17, 2016

13.1K
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

8.5K
Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture
07:05

Single-cell Resolution Fluorescence Live Imaging of Drosophila Circadian Clocks in Larval Brain Culture

Published on: January 19, 2018

7.8K

Area of Science:

  • Neuroscience
  • Chronobiology
  • Cognitive Science

Background:

  • The suprachiasmatic nucleus acts as the master circadian clock, regulating peripheral oscillators.
  • Emerging evidence indicates a distinct circadian clock within the hippocampus, potentially governing learning and memory.
  • This hippocampal clock may operate independently of, yet be influenced by, the master clock and learning processes.

Purpose of the Study:

  • To propose a theoretical mechanism for how the hippocampal circadian clock locally determines its entrainment.
  • To introduce a novel framework extending the 'hippocampal memory clock' concept.
  • To offer a new perspective on the coordination of circadian rhythms across the brain.

Main Methods:

  • Theoretical modeling and framework development.
  • Conceptual extension of existing 'hippocampal memory clock' research.
  • Analysis of potential entrainment mechanisms for local circadian oscillators.

Main Results:

  • A proposed mechanism for local entrainment of the hippocampal circadian clock.
  • A theoretical framework suggesting how brain circadian clocks coordinate their rhythms.
  • Implication that daily learning at consistent times may enhance hippocampal-dependent memory.

Conclusions:

  • The hippocampus may possess a local circadian clock capable of independent entrainment.
  • This local clock mechanism has implications for understanding memory consolidation and circadian rhythm disruption.
  • Potential for developing non-invasive therapies to mitigate negative health effects of circadian desynchronization.