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Acute myocardial ischemia: MR imaging with Mn-TP
P W Pflugfelder1, M F Wendland, W W Holt
1Department of Radiology, University of California, San Francisco 94143.
Radiology
|April 1, 1988
Summary
Manganese ethylenediaminetetraphosphonate (Mn-TP) enhances cardiac MRI signal intensity, aiding in the detection of myocardial ischemia. This contrast agent effectively delineates jeopardized heart tissue after coronary artery occlusion in rats.
Area of Science:
- Cardiovascular Imaging
- Medical Imaging Physics
- Pharmacology
Background:
- Cardiac magnetic resonance (MR) imaging is crucial for assessing heart conditions.
- Developing effective contrast agents is key to improving diagnostic accuracy.
- Manganese ethylenediaminetetraphosphonate (Mn-TP) is a potential MRI contrast agent.
Purpose of the Study:
- To evaluate the effects of Mn-TP on cardiac MR imaging in rats.
- To determine Mn-TP's efficacy in delineating myocardial ischemia.
Main Methods:
- Cardiac-gated spin-echo MR imaging was performed in rats before and after intravenous Mn-TP injection.
- Signal intensity and T1 relaxation times of myocardial tissue were measured.
- Myocardial ischemia was induced via left anterior descending coronary artery occlusion.
Main Results:
- Mn-TP significantly increased cardiac signal intensity by over 70% in normal myocardium.
- T1 relaxation times were significantly reduced in Mn-TP treated rats compared to controls.
- In ischemic myocardium, Mn-TP showed a limited signal increase, creating contrast with normal tissue.
Conclusions:
- Mn-TP acts as an effective cardiac MR imaging contrast agent in rats.
- The differential enhancement between normal and ischemic myocardium suggests Mn-TP's potential for diagnosing acute myocardial ischemia.
- T1-weighted MR imaging with Mn-TP may help delineate jeopardized cardiac regions.