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Updated: Nov 20, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers

Xiangyu Li1, Woonghee Kim1, Muhammad Arif1

  • 1Science for Life Laboratory, KTH-Royal Institute of Technology, SE-17165 Stockholm, Sweden.

Cancers
|January 22, 2021
PubMed
Summary

Pyruvate kinase muscle type (PKM) transcripts show varied prognostic value in 25 cancers. Some PKM variants, including novel ones, influence patient survival and may play roles in cancer metabolism and invasion.

Keywords:
PKMalternative splicingcancertranscriptomics

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