Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

97
Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
97
Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids01:31

Acid Suppressive Drugs for Peptic Ulcer Disease: Antacids

510
In the complex environment of the gastric lumen, excessive acid secretion can lead to the formation or worsening of ulcers within the delicate mucosal layer. Antacids, such as sodium bicarbonate and calcium carbonate, provide relief by neutralizing this acid, transforming it into harmless salt and water. This neutralization process raises the gastric pH from a highly acidic level of 1 to a more basic 3-4, reducing the acidity within the stomach.
However, this neutralization reaction between...
510
Drug Dosage Regimen: Overview01:15

Drug Dosage Regimen: Overview

4.1K
A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
Typically, the starting dose and dosing interval are guided by the manufacturer's recommendations based on clinical trials conducted during and after drug...
4.1K
Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors01:13

Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors

672
Peptic ulcers, often induced by H. pylori infections or NSAID usage, arise from disruptions in the delicate balance of gastric acid production. Peptic ulcers stem from heightened gastric acid levels due to H. pylori infections or NSAID use. The protective mucus layer diminishes in the presence of these factors, allowing gastric acid to erode the stomach lining and form ulcers.
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
672
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

85
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
85
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.5K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective inhibition of interleukin 6 receptor decreased inflammatory cytokines and increased proteases in an experimental model of critical calvarial defect.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2024
Same author

Macrophage Polarization during MRONJ Development in Mice.

Journal of dental research·2024
Same author

Nivolumab-induced lichenoid granulomatous stomatitis in a patient with advanced melanoma: A case report.

Molecular and clinical oncology·2022
Same author

Task Force on Design and Analysis in Oral Health Research: Medication-Related Osteonecrosis of the Jaw.

JDR clinical and translational research·2019
Same author

p38 Expression and Modulation of STAT3 Signaling in Oral Cancer.

Pathology oncology research : POR·2018
Same author

Prostaglandins E<sub>2</sub> and F<sub>2α</sub> Enhance Differentiation of Cementoblastic Cells.

Journal of periodontology·2018
Same journal

Reorienting Oral Health Promotion through Systems Thinking.

Journal of dental research·2026
Same journal

<i>Porphyromonas gingivalis</i>-Induced NETs Mediate Neuroinflammation via TLR4 Activation.

Journal of dental research·2026
Same journal

Oral Burden of Sjögren Disease: A Systematic Review and Meta-analysis.

Journal of dental research·2026
Same journal

Gingival Fibroblast-Driven Osteoimmunology via the IL-33-ILC2-IL-13 Axis.

Journal of dental research·2026
Same journal

Advancing a Global Oral Health Research Agenda.

Journal of dental research·2026
Same journal

YAP/TAZ Drive Oral Leukoplakia Progression and Confer Ferroptosis Vulnerability.

Journal of dental research·2026
See all related articles

Related Experiment Video

Updated: Nov 20, 2025

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
04:19

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

Published on: January 13, 2023

4.9K

Antiresorptive-Type and Discontinuation-Timing Affect ONJ Burden.

D Hadaya1, A Soundia1, I Gkouveris1

  • 1Division of Diagnostic and Surgical Sciences, UCLA School of Dentistry, Los Angeles, CA, USA.

Journal of Dental Research
|January 22, 2021
PubMed
Summary
This summary is machine-generated.

Discontinuing antiresorptive medications like zoledronic acid (ZA) or OPG-Fc before tooth extraction may prevent osteonecrosis of the jaws (ONJ). However, stopping these drugs does not resolve existing ONJ.

Keywords:
bone biologybone remodeling/regenerationoral and maxillofacial surgeryosteoclastsosteonecrosisosteoporosis

More Related Videos

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.9K
Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

853

Related Experiment Videos

Last Updated: Nov 20, 2025

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
04:19

The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model

Published on: January 13, 2023

4.9K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.9K
Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

853

Area of Science:

  • Oral and Maxillofacial Surgery
  • Pharmacology
  • Oncology

Background:

  • Osteonecrosis of the jaws (ONJ) is a serious complication associated with antiresorptive medications.
  • Current management strategies include symptom control, surgical intervention, and temporary drug cessation (drug holidays).

Purpose of the Study:

  • To investigate the efficacy of antiresorptive discontinuation in preventing and treating osteonecrosis of the jaws (ONJ) in a rat model.
  • To evaluate the impact of zoledronic acid (ZA) and OPG-Fc (denosumab surrogate) discontinuation timing on ONJ development and resolution.

Main Methods:

  • Rats were pretreated with ZA or OPG-Fc, followed by induction of ONJ via periapical disease and tooth extraction.
  • Two experimental designs were used: 1) antiresorptive discontinuation 1 week prior to extraction, and 2) antiresorptive discontinuation after ONJ was established.
  • Clinical, radiographic, and histological assessments were performed to evaluate ONJ features.

Main Results:

  • Discontinuation of OPG-Fc before tooth extraction ameliorated ONJ development, while ZA discontinuation did not show a similar preventive effect.
  • Discontinuing either ZA or OPG-Fc in rats with established ONJ did not promote resolution of the condition.

Conclusions:

  • Antiresorptive discontinuation efficacy for ONJ management is dependent on the specific drug and the timing of cessation.
  • Drug holidays may be beneficial for ONJ prevention but not for established ONJ resolution.