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Transdermal Drug Delivery Systems

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Published on: June 1, 2012

Graphene nanocomposites for transdermal biosensing.

Tanveer A Tabish¹, Aumber Abbas², Roger J Narayan³

¹UCL Cancer Institute, University College London, London, UK.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology

|January 22, 2021

Summary

Graphene-based transdermal biosensors offer a non-invasive way to continuously monitor disease biomarkers. These microneedle devices provide accurate, real-time health insights, addressing a key clinical need.

Keywords:

glucose graphene hydrogen peroxide microneedles transdermal biosensing

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Transdermal biosensors enable non-invasive, continuous health monitoring.
Current microneedle biosensors face challenges in accuracy and reliability for disease monitoring.
There is a need for advanced biosensing technologies to monitor intradermal biomarkers.

Purpose of the Study:

To explore the application of graphene-based transdermal biosensors for health monitoring.
To evaluate the potential of these sensors for detecting critical biomarkers like glucose and hydrogen peroxide.
To review recent innovations and challenges in graphene biosensing technology.

Main Methods:

Focus article reviewing existing literature and research on graphene transdermal biosensors.
Evaluation of in vitro, in vivo, and ex vivo studies on graphene-based sensor performance.
Analysis of material properties of graphene for analyte quantification.

Main Results:

Graphene's unique properties facilitate the quantification of analytes and physiological status.
Graphene-based biosensors show promise for detecting biomarkers indicative of disease.
Demonstrated potential for glucose and hydrogen peroxide detection.

Conclusions:

Graphene-based transdermal biosensors represent a significant advancement in diagnostic tools.
These devices offer a user-friendly, affordable, and non-invasive approach to personalized health monitoring.
Addressing technological gaps can lead to improved real-world clinical problem-solving.