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All in One: Stimuli-Responsive, Efficient Mitotracking, and Single Source White Light Emission.
Bibhisan Roy1,2, Mallu Chenna Reddy1, Gregor P Jose3
1Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, Maharashtra 411008, India.
The Journal of Physical Chemistry Letters
|January 22, 2021
Summary
Researchers developed novel organic luminogens that emit white light and track mitochondria. These "all-in-one" probes also exhibit temperature-responsive color changes, advancing optical and biological imaging.
Area of Science:
- Organic Chemistry
- Materials Science
- Biomedical Imaging
Background:
- The demand for multifunctional luminogens (
Purpose of the Study:
- To develop novel luminogens with combined optical, material, and biological properties.
- To achieve white light emission, stimuli-responsive behavior, and efficient mitochondrial tracking in a single probe.
Main Methods:
- Synthesis and characterization of novel organic luminogens (DPAEOA and DPAPMI).
- Investigation of optical properties, including white light emission and mechanochromism.
- Evaluation of mitochondrial targeting efficiency using fluorescence microscopy.
Main Results:
- A pair of luminogens exhibiting white light emission (CIE coordinates: 0.35, 0.35 and 0.29, 0.33) were synthesized.
- The probes demonstrated temperature-induced mechanochromic behavior linked to crystal packing (space group P-1).
- The neutral probe DPAEOA achieved highly specific mitochondrial illumination (Pearson coefficient: 0.93), outperforming typical cationic trackers.
Conclusions:
- This study presents the first "all-in-one" luminogen with white light emission, mechanochromism, and efficient mitochondrial tracking.
- The findings offer a new strategy for designing advanced organic luminogens for diverse applications.
- The developed probes hold significant potential for optical, materials, and biological fields.
