Penile and scrotal infundibular cysts in an adolescent treated with sorafenib

Area of Science:

• Dermatology
• Oncology
• Pharmacology

Background:

• Sorafenib is a multikinase inhibitor used to treat various solid tumors.
• Previous reports have documented keratotic lesions, including squamous cell carcinoma and actinic keratosis, associated with sorafenib therapy.
• Infundibular cysts are also a known, albeit less common, potential adverse effect.

Observation:

• A 15-year-old male patient with desmoid fibromatosis was undergoing treatment with sorafenib.
• The patient developed multiple infundibular cysts.
• These lesions were located on the penile and scrotal regions.

Findings:

• The development of multiple penile and scrotal infundibular cysts was observed in a young male patient during sorafenib treatment for desmoid fibromatosis.
• This case adds to the spectrum of dermatological side effects associated with sorafenib.
• The specific presentation of multiple genital infundibular cysts is noteworthy.

Implications:

• Clinicians should be aware of the potential for genital infundibular cyst formation as a side effect of sorafenib.
• This finding may prompt further investigation into the mechanisms underlying sorafenib-induced adnexal lesions.
• Monitoring for and managing these dermatological adverse events is crucial for patient care during sorafenib therapy.