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Related Concept Videos

Antigen Presenting Cells01:22

Antigen Presenting Cells

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The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Cells of the Adaptive Immune Response01:23

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Cell-mediated Immune Responses01:40

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B Cell Activation and Differentiation01:24

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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
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Updated: Nov 20, 2025

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

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Dendritic Cells Revisited.

Mar Cabeza-Cabrerizo1, Ana Cardoso1, Carlos M Minutti1

  • 1Immunobiology Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom;

Annual Review of Immunology
|January 22, 2021
PubMed
Summary
This summary is machine-generated.

Conventional dendritic cells (cDCs) are a distinct cell lineage that shapes immunity. This review clarifies cDC subsets, development, and functions, distinguishing them from other dendritic cell types.

Keywords:
Langerhans cellsadaptive immunitydendritic cellsinnate immunitymonocytesmyelopoiesis

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Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are crucial for adaptive and innate immunity, integrating environmental cues and communicating with leukocytes.
  • Historically, various cell types have been identified as DCs based on phenotype and function, leading to field complexity.

Purpose of the Study:

  • To refocus on conventional dendritic cells (cDCs) as a specific lineage.
  • To summarize current knowledge on mouse and human cDC subsets, including their development and characteristics.
  • To clarify the distinction between cDCs and other related cell types.

Main Methods:

  • Review of existing literature on dendritic cell biology.
  • Analysis of ontogenetic and gene expression criteria for cell lineage definition.
  • Comparison of phenotypic and functional attributes across different dendritic cell populations.

Main Results:

  • Conventional dendritic cells (cDCs) represent a discrete cell lineage, aligning with cells originally described in the 1970s.
  • Detailed summary of known mouse and human cDC subsets, their hematopoietic origins, and key features.
  • Distinction established between cDCs and other cell types previously categorized as DCs.

Conclusions:

  • Clarifying cDC biology enhances understanding of their unique immunological roles.
  • Distinguishing cDCs from related cell types simplifies the complex field of dendritic cell research.
  • This review highlights the remarkable properties of cDCs and aids in navigating the intricate landscape of DC biology.