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Related Experiment Video

Updated: Nov 20, 2025

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First in Human: Transcatheter, Transapical Double Valve Replacement.

Ilinca Damian1, Joerg Kellermair2, Michael Grund2

  • 1Department of Cardiothoracic and Vascular Surgery, Kepler University Hospital, Medical Faculty Johannes Kepler University Linz, Linz, Austria.

The Annals of Thoracic Surgery
|January 22, 2021
PubMed
Summary
This summary is machine-generated.

Transcatheter double valve replacement offers a safe, effective, and minimally invasive option for severe aortic stenosis and mitral regurgitation in high-risk patients. This novel approach avoids cardiopulmonary bypass, significantly reducing procedure time and improving outcomes.

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Minimally Invasive Surgery

Background:

  • Transcatheter aortic valve replacement (TAVR) is standard for severe aortic stenosis in high-risk patients.
  • Transcatheter mitral valve replacement (TAVR) is an emerging treatment for severe mitral regurgitation.
  • Combined severe aortic stenosis and mitral regurgitation pose significant therapeutic challenges.

Observation:

  • This report details the first transcatheter, transapical native double valve replacement.
  • The procedure addressed both severe aortic stenosis and severe mitral regurgitation simultaneously.
  • The intervention was performed without cardiopulmonary bypass.

Findings:

  • The transcatheter double valve replacement was demonstrated as a safe and effective procedure.
  • Procedural time was significantly reduced compared to traditional open-heart surgery.
  • The technique successfully managed both aortic and mitral valve pathologies concurrently.

Implications:

  • This minimally invasive approach may benefit high-risk surgical patients with complex valve disease.
  • Reduced procedural time and avoidance of cardiopulmonary bypass can improve patient recovery.
  • This technique represents a promising advancement in transcatheter structural heart interventions.