Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cerebellum: Anatomical Regions01:17

Cerebellum: Anatomical Regions

3.2K
The cerebellum, also known as the "little brain," is located in the posterior cranial fossa, inferior to the tentorium cerebelli and dorsal to the brainstem. It plays a significant role in motor control, coordination, and proprioception.
Cerebellar Structure
Externally, the cerebellum features a highly convoluted surface with numerous folia (narrow ridges) separated by shallow sulci (grooves). The cerebellum is divided into two hemispheres by a thin median structure known as the vermis. The...
3.2K
Cerebrospinal Fluid01:21

Cerebrospinal Fluid

4.0K
Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain....
4.0K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

3.4K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
3.4K
Cerebrum: Anatomical Overview I01:26

Cerebrum: Anatomical Overview I

3.8K
The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...
3.8K
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

779
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
779

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A predictive map learned from diverse entorhinal inputs explains the role of context-dependent reorganization of hippocampal place cells.

Frontiers in computational neuroscience·2026
Same author

Consensus Paper: Models of Cerebellar Functions.

Cerebellum (London, England)·2026
Same author

A theory of cerebellar learning as spike-based reinforcement learning in continuous time and space.

PNAS nexus·2025
Same author

Dissociation Between Tumor Response and PTTM Progression During Entrectinib Therapy in NTRK Fusion-Positive Colon Cancer.

Current oncology (Toronto, Ont.)·2025
Same author

Requirement of Lysosomal Two-Pore Channels for Normal Fertilization and Artificial Oocyte Activation in Mice.

Frontiers in bioscience (Landmark edition)·2025
Same author

A spiking network model of the cerebellum for predicting movements with diverse complex spikes.

Neural networks : the official journal of the International Neural Network Society·2025

Related Experiment Video

Updated: Nov 20, 2025

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

4.3K

Human-scale Brain Simulation via Supercomputer: A Case Study on the Cerebellum.

Tadashi Yamazaki1, Jun Igarashi2, Hiroshi Yamaura1

  • 1Graduate School of Informatics and Engineering, The University of Electro-Communications, Japan.

Neuroscience
|January 22, 2021
PubMed
Summary

Large-scale brain simulations using supercomputers are now possible, enabling detailed models of the human brain. This research explores human-scale neural network simulations for advancing computational neuroscience.

Keywords:
CerebellumComputer simulationHuman-scale brain simulationSpiking networkSupercomputer

More Related Videos

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.1K
Modeling Human Cerebellar Development In Vitro in 2D Structure
06:14

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

1.9K

Related Experiment Videos

Last Updated: Nov 20, 2025

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging
11:50

A Standardized Pipeline for Examining Human Cerebellar Grey Matter Morphometry using Structural Magnetic Resonance Imaging

Published on: February 4, 2022

4.3K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.1K
Modeling Human Cerebellar Development In Vitro in 2D Structure
06:14

Modeling Human Cerebellar Development In Vitro in 2D Structure

Published on: September 16, 2022

1.9K

Area of Science:

  • Computational Neuroscience
  • Neuroscience
  • High-Performance Computing

Background:

  • Supercomputer performance has grown exponentially, enabling complex simulations.
  • Large-scale neural network models with billions of neurons and trillions of synapses are feasible.
  • Human-scale brain simulation represents a milestone for neuroscience.

Purpose of the Study:

  • To provide an overview of large-scale brain simulation on supercomputers.
  • To review existing large-scale simulation studies, with a focus on the cerebellum.
  • To present results from a human-scale cerebellar network model.

Main Methods:

  • Utilizing modern high-performance computing technology for neuroscience research.
  • Developing and simulating large-scale neural network models with detailed parameters.
  • Reviewing and analyzing representative large-scale simulation studies.

Main Results:

  • Demonstrated the feasibility of simulating a human-scale cerebellar network model (86 billion neurons).
  • Presented simulation results from the Japanese flagship supercomputer K.
  • Reviewed various large-scale simulation studies and cerebellum-specific research.

Conclusions:

  • Human-scale brain simulation is crucial for advancing computational and general neuroscience.
  • High-performance computing is essential for achieving these simulation milestones.
  • Future research should focus on further developing large-scale brain simulation techniques.