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Endocrine disorders in men infected with human immunodeficiency virus
A S Dobs1, M A Dempsey, P W Ladenson
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
The American Journal of Medicine
|March 1, 1988
Summary
Hypogonadism is a common endocrine issue in men with human immunodeficiency virus (HIV) infection. This hormonal imbalance may manifest early, even before other symptoms of acquired immunodeficiency syndrome (AIDS) appear.
Area of Science:
- Endocrinology
- Infectious Diseases
- Immunology
Background:
- Human immunodeficiency virus (HIV) infection can impact various bodily systems.
- Endocrine dysfunction is a potential complication in individuals with HIV/AIDS.
Purpose of the Study:
- To evaluate gonadal, adrenal, and thyroid functions in men with HIV infection.
- To determine the prevalence and characteristics of endocrine abnormalities in HIV-positive men across different clinical stages.
Main Methods:
- Assessed endocrine function (gonadal, adrenal, thyroid) in 70 HIV-seropositive men.
- Categorized patients into asymptomatic, AIDS-related complex (ARC), and acquired immunodeficiency syndrome (AIDS) groups.
- Measured serum testosterone, gonadotropin response, and cortisol reserve.
Main Results:
- Hypogonadism was prevalent, particularly in AIDS patients (50%).
- Significantly lower mean serum testosterone levels were observed in ARC and AIDS groups compared to asymptomatic and normal men.
- Hypogonadotropic hypogonadism was common, and adrenal and thyroid functions were generally preserved.
Conclusions:
- Hypogonadism is a frequent endocrine abnormality in men with HIV infection.
- It may serve as an early or sensitive indicator of disease progression.
- Endocrine monitoring is crucial for managing HIV-infected individuals.