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Published on: January 28, 2020
The cardiovascular disorders and prognostic cardiac biomarkers in COVID-19
Xingjuan Shi1, Mengying Chen2, Yu Zhang2
1School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210096, China. xingjuanshi@seu.edu.cn.
Insights
Coronavirus disease 2019 (COVID-19) impacts the heart, not just the lungs. This review explores cardiovascular issues in COVID-19, potential mechanisms, and cardiac biomarkers for better patient outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Virology
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19, a global pandemic.
- While primarily a respiratory illness, cardiovascular complications are increasingly recognized in COVID-19 patients.
Purpose of the Study:
- To review cardiac disorders associated with coronavirus infections in humans and animals.
- To focus on the link between SARS-CoV-2 infection and cardiovascular disorders.
- To identify prognostic cardiac biomarkers for COVID-19 and explore mechanisms of cardiac injury.
Main Methods:
- Literature review of studies on coronavirus and cardiac involvement.
- Analysis of associations between SARS-CoV-2 and cardiovascular disorders.
- Discussion of potential mechanisms of cardiac injury, including direct viral damage, ACE2 reduction, and inflammation.
Main Results:
- Various coronaviruses can cause cardiac issues in humans and animals.
- SARS-CoV-2 infection is linked to significant cardiovascular complications.
- Key prognostic cardiac biomarkers and underlying injury mechanisms are discussed.
Conclusions:
- Understanding COVID-19's cardiac effects is crucial for predicting clinical outcomes.
- Insights into cardiac involvement can guide more effective treatment strategies for COVID-19 patients.
Abstract:
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to the outbreak of coronavirus disease 2019 (COVID-19), a worldwide epidemic disease affecting increasing number of patients. Although the virus primarily targets respiratory system, cardiovascular involvement has been reported in accumulating studies. In this review, we first describe the cardiac disorders in human with various types of CoV infection, and in animals infected with coronavirus. Particularly, we will focus on the association of cardiovascular disorders upon SARS-CoV-2 infection, and prognostic cardiac biomarkers in COVID-19. Besides, we will discuss the possible mechanisms underlying cardiac injury resulted from SARS-CoV-2 infection including direct myocardial injury caused by viral infection, reduced level of ACE2, and inflammatory response during infection. Improved understandings of cardiac disorders associated with COVID-19 might predict clinical outcome and provide insights into more rational treatment responses in clinical practice.
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