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NAD+ and cardiovascular diseases.

Qiuzhen Lin1, Wanyun Zuo1, Yaozhong Liu1

  • 1Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, PR China; Research Institute of Blood Lipid and Atherosclerosis, Central South University, PR China; Modern Cardiovascular Disease Clinical Technology Research Center of Hunan Province, PR China; Cardiovascular Disease Research Center of Hunan Province, Changsha Hunan 410011, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
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PubMed
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Nicotinamide adenine dinucleotide (NAD) is crucial for heart health. Maintaining NAD+ levels protects against cardiovascular diseases like heart failure and hypertension, suggesting NAD+ boosting strategies are vital.

Keywords:
Biological processesCardiovascular diseaseNAD(+)NADHSIRTs

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Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Metabolic Regulation

Background:

  • Nicotinamide adenine dinucleotide (NAD) is a vital coenzyme involved in numerous cellular processes.
  • The NAD+/NADH ratio is critical for maintaining cellular redox homeostasis and energy metabolism.
  • NAD+ is implicated in key pathways relevant to cardiovascular disease, including those involving PARP1, CD38, CD157, and sirtuins.

Purpose of the Study:

  • To review the role of NAD+ in the pathogenesis of cardiovascular diseases.
  • To explore the potential of NAD+ boosting strategies for improving cardiovascular health.

Main Methods:

  • Literature review focusing on NAD+ metabolism and cardiovascular disease.
  • Analysis of NAD+ involvement in conditions such as metabolic syndrome, heart failure, ischemia-reperfusion injury, arrhythmia, and hypertension.

Main Results:

  • NAD+ plays a protective role against various cardiovascular conditions.
  • Loss of NAD+ during aging or stress contributes to metabolic dysfunction and disease susceptibility.
  • Maintaining NAD+ levels or implementing NAD+ boosting strategies is essential for cardiac health.

Conclusions:

  • NAD+ is a critical factor in cardiovascular homeostasis and disease prevention.
  • Targeting NAD+ metabolism offers promising therapeutic avenues for cardiovascular diseases.
  • Further research into NAD+ boosting strategies is warranted for cardiovascular health enhancement.