Validation of a Portable Blood Gas Analyzer for Use in Challenging Field Conditions at High Altitude

Novel, portable blood gas analyzers (BGAs) may serve as essential point-of-care tools in remote regions, during air travel or in ambulance services but they have not been extensively validated.

We compared accuracy of a portable BGA to a validated stationary device.

In healthy individuals and patients with chronic obstructive pulmonary disease participating in clinical field studies at different altitudes, arterial blood samples were obtained at rest and during exercise in a hospital at 760 m and in a high altitude clinic at 3100 m. Paired measurements by a portable BGA (EPOC, Siemens Healthcare) and a stationary BGA (Rapidpoint500, Siemens Healthcare) were performed to compute bias (mean difference) and limits of agreement (95% CI of bias).

Of 105 individuals, 248 arterial blood samples were analyzed, 108 at 760 m, 140 at 3100 m. Ranges of values measured by portable BGA were: pH 7.241-7.473, PaCO₂ 21.5-52.5 mmHg, and PaO₂ 45.5-107.1 mmHg. Bias (95% CI) between devices were: pH 0.007 (-0.029 to 0.044), PaCO₂ -0.3 mmHg (-4.8 to 4.2), and PaO₂ -0.2 mmHg (-9.1 to 4.7). For pH, agreement between devices was improved by the equation to correct pH by portable BGA = -1.37 + pH × 1.19; bias after correction -0.007 (-0.023 to 0.009). The portable BGA was easily handled and worked reliably.

Accuracy of blood gas analysis by the portable BGA in comparison to the reference BGA was adequate for clinical use. Because of portability and ease of handling, portable BGA are valuable diagnostic tools for use in everyday practice as well as under challenging field conditions.