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Graves' Disease Presenting as Urticaria
Mohammed A Al Rushud1, Mohammed Gaffar Mohammed2, Abdulrahman Murshid3
1Internal Medicine, Alfaisal University, Riyadh, SAU.
Cureus
|January 25, 2021
Summary
Graves' disease, an autoimmune condition, can manifest with urticaria. This case highlights a patient initially presenting with only urticaria, later developing thyrotoxicosis and an allergic reaction to treatment.
Area of Science:
- Endocrinology
- Immunology
- Dermatology
Background:
- Graves' disease (GD) is an autoimmune disorder targeting the thyroid gland, often causing thyrotoxicosis.
- Urticaria, characterized by wheals and/or angioedema, is an immune-mediated response involving mast cell activation.
Observation:
- This report details a case where a patient presented with urticaria as the sole initial symptom.
- The patient subsequently developed symptoms of thyrotoxicosis, a common manifestation of Graves' disease.
Findings:
- The association between Graves' disease and urticaria is recognized, though urticaria as the sole presenting complaint is uncommon.
- The patient experienced an allergic reaction to carbimazole, a medication used to treat hyperthyroidism.
Implications:
- This case underscores the importance of considering Graves' disease in patients presenting with unexplained urticaria.
- It also highlights potential treatment complexities, such as drug allergies, in managing Graves' disease.
- Further research may elucidate the specific mechanisms linking autoimmune thyroid disease and dermatological manifestations like urticaria.
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