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Pharmacological modulation of cold-induced pain in cutaneous leiomyomata
C B Archer1, S Whittaker, M W Greaves
1St John's Hospital for Diseases of the Skin, Leicester Square, London, U.K.
The British Journal of Dermatology
|February 1, 1988
Abstract:
In two patients with painful cutaneous leiomyomata, induction of pain by the application of an ice cube allowed assessment of a number of topical and systemic treatments aimed at reducing or preventing the pain. In one patient the alpha-adrenoceptor blocker, phenoxybenzamine alleviated cold-induced pain. In the second patient, topical 9% hyoscine hydrobromide (an anticholinergic agent) decreased pain induced by the ice cube, but was not helpful in reducing lesional pain due to cold weather.