Related Experiment Video
Updated: Nov 20, 2025
10:09
Leprdb Mouse Model of Type 2 Diabetes: Pancreatic Islet Isolation and Live-cell 2-Photon Imaging Of Intact Islets
Published on: May 11, 2015
9.8K
What's in a Name? Redefining Type 2 Diabetes Remission
Sanjay Kalra1, Arbinder Singal2, Tejal Lathia3
1Department of Endocrinology, Bharti Hospital, Karnal, India. brideknl@gmail.com.
Summary
Achieving diabetes remission means reaching normal blood sugar levels for six months without diabetes complications. This new framework clarifies the definition for type 2 diabetes remission.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Clinical Definitions
Background:
- Diabetes remission is a widely discussed but inconsistently defined clinical outcome.
- Existing definitions lack a unified, comprehensive framework, leading to ambiguity in research and practice.
Purpose of the Study:
- To critically evaluate current definitions of diabetes remission.
- To propose a contemporary and comprehensive framework for defining type 2 diabetes remission.
Main Methods:
- This is an opinion piece and conceptual analysis.
- Review of existing literature and clinical understanding of diabetes remission criteria.
Main Results:
- A proposed definition for type 2 diabetes remission is presented.
- Remission is characterized by achieving a target HbA1c level sustained for at least six months.
Conclusions:
- The proposed framework defines diabetes remission as a healthy state achieved through lifestyle changes or metformin, excluding other causes.
- This standardized definition aims to improve clarity and consistency in the clinical management and research of type 2 diabetes.
Keywords:
Calorie restriction mimicryCureEuglycemiaLifestyle modificationMetforminRemission of diabetesReversal of diabetesType 2 diabetesMore Related Videos
11:31High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model
Published on: August 16, 2019
8.2K
06:27Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
17.1K
Related Concept Videos
01:22Diabetes Mellitus: Type 2 and Gestational
3.8K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.8K
01:36Carbohydrate Metabolism
13.0K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.0K
01:15Diabetes: Management and Pharmacotherapy
707
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
707
01:22Diabetes Mellitus: Overview and Type I Subtype
4.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.3K
01:15Diabetes: Symptoms, Diagnosis, and Complications
1.5K
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
1.5K
01:20Pathophysiology of Diabetes
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.4K