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Updated: Nov 20, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Transfusion management for children supported by extracorporeal membrane oxygenation
Oliver Karam1, Marianne E Nellis2
1Division of Pediatric Critical Care Medicine, Children's Hospital of Richmond at VCU, Richmond, Virginia.
Abstract:
Due to the patients' underlying illness, in combination with circuit-induced coagulopathy, as well as PLT dysfunction, children supported by ECMO are a risk of receiving large volumes of blood components. Given the increasing use of modified blood products and newer biologics, it is unknown whether these products have equal efficacy and safety, in ECMO. The majority of guidance for transfusion therapy is based on expert opinion alone, and research on indications for RBC, plasma, and PLT transfusions for children on ECMO should be a priority.
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