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[Cellular oncogene expression in human tumors transplantable to athymic mice]
Biulleten' Eksperimental'Noi Biologii I Meditsiny
|March 1, 1988
Summary
Three cellular oncogenes (c-myc, c-fos, c-ras) are commonly expressed in human tumors grown in mice. Their expression levels were higher than in primary tumors, except for melanoma Mel-2 which showed c-myb expression.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Context:
- Investigating cellular oncogene expression in human tumor xenografts.
- Analyzing gene expression patterns across diverse human tumor types.
- Utilizing nude mouse models for in vivo tumor studies.
Purpose:
- To identify commonly expressed cellular oncogenes in human tumors.
- To compare oncogene expression levels between xenografts and primary tumors.
- To determine oncogene expression specificity across different tumor types.
Summary:
- Expression of c-myc, c-fos, and c-ras oncogenes was detected in most of the 20 human tumor strains passaged in nude mice.
- These three oncogenes showed higher expression levels in xenografts compared to primary human tumors.
- Human melanoma Mel-2 strain uniquely expressed c-myb, while c-mos, B-lym, c-sis, and c-myb were not expressed in the examined strains.
Impact:
- Provides insights into oncogene dysregulation in cancer progression.
- Highlights potential biomarkers for tumor detection and characterization.
- Informs the development of targeted cancer therapies.
