The Free and Cued Selective Reminding Test Predicts Braak Stage

Area of Science:

• Neurology
• Gerontology
• Biomarkers

Background:

• Clinical markers for Alzheimer's disease (AD) require validation against AD neuropathology.
• Early detection of AD pathology is crucial for timely intervention.

Purpose of the Study:

• To identify clinical measures that predict Alzheimer's disease neuropathology.
• To evaluate the sensitivity of pFCSRT+IR, MMSE, and CDR-SB in relation to Braak stage.

Main Methods:

• Analysis of 315 clinicopathological cases from the Knight Alzheimer's Disease Research Center.
• Comparison of pFCSRT+IR, MMSE, and CDR-SB performance in predicting Braak stage using ordinal logistic regression.

Main Results:

• Free recall scores on pFCSRT+IR were lower in Braak stage III compared to stages 0/I.
• MMSE and CDR-SB scores did not differ significantly until Braak stage IV.
• pFCSRT+IR scores demonstrated higher predictive validity for Braak stage than MMSE and CDR-SB.

Conclusions:

• The pFCSRT+IR may be more sensitive to early Alzheimer's disease pathological changes than the CDR-SB or MMSE.
• pFCSRT+IR shows potential as an early predictive biomarker for AD neuropathology.