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FGF10 and FGF13 genetic variation and tooth-size discrepancies.
The Angle Orthodontist
|January 25, 2021
Summary
Genetic variations in FGF10 and FGF13 are linked to tooth-size discrepancies. Specific alleles in these genes increase the likelihood of developing larger teeth, impacting dental development.
Area of Science:
- Genetics
- Odontology
- Orthodontics
Background:
- Tooth-size discrepancies can affect orthodontic treatment outcomes.
- Understanding the genetic basis of tooth size is crucial for personalized dental care.
Purpose of the Study:
- To investigate the association between variations in odontogenesis-related genes and tooth-size discrepancies.
- To identify specific genetic markers that may predispose individuals to abnormal tooth proportions.
Main Methods:
- Genotyping of 13 single nucleotide polymorphisms (SNPs) in nine genes from 62 orthodontic patients.
- Analysis of dental cast measurements to classify tooth-size discrepancies (Bolton ratios).
- Statistical analysis (Chi-square, Fisher exact tests, Odds Ratios) to determine genotype/allele associations.
Main Results:
- The FGF10 rs900379 T allele was associated with larger mandibular teeth (OR=3.74, P=.002), with a stronger effect in homozygous individuals (OR=6.16, P=.006).
- FGF13 rs5931572 rare homozygotes showed an increased risk for tooth-size discrepancies (OR=10.32, P=.003).
Conclusions:
- FGF10 and FGF13 gene variations are potential contributors to tooth-size discrepancies.
- These findings may inform future genetic screening for orthodontic conditions.
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