CD34+ cells and endothelial progenitor cell subpopulations are associated with cerebral small vessel disease burden
Zhi-Xin Huang1,2,3, Jin Fang4, Chang-Hua Zhou5
1Stroke Center & Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China.
Insights
Circulating CD34-positive cells and endothelial progenitor cells may indicate cerebral small vessel disease (CSVD) progression. Lower CD34+ cells suggest higher CSVD burden, while specific progenitor cells indicate disease advancement.
Area of Science:
- Neurology
- Vascular Biology
- Cell Biology
Background:
- Endothelial dysfunction is implicated in cerebral small vessel disease (CSVD) pathogenesis.
- Endothelial progenitor cells are linked to endothelial dysfunction.
Purpose of the Study:
- To investigate the relationship between circulating CD34-positive cells, endothelial progenitor cells, and CSVD burden.
- To identify potential biomarkers for monitoring CSVD progression.
Main Methods:
- Prospective study including 364 patients with confirmed CSVD.
- Analysis of circulating CD34-positive cells and specific endothelial progenitor cell populations.
- Ordinal logistic regression to assess correlations with CSVD burden.
Main Results:
- Higher CSVD burden correlated with significantly decreased circulating CD34+ cell levels (OR, 0.42; p=0.034).
- Higher CSVD burden correlated with significantly increased circulating CD34+CD133+CD309+ cells (OR, 1.07; p=0.031) and CD34+CD133+ cells (OR, 1.03; p=0.001).
Conclusions:
- Circulating CD34+ cells, CD34+CD133+CD309+ cells, and CD34+CD133+ cells show potential as biomarkers for CSVD progression.
- These cell populations may help monitor disease advancement in patients with CSVD.
Abstract:
Background: Endothelial dysfunction is considered to be involved in the pathogenesis of cerebral small vessel disease (CSVD). Endothelial progenitor cells are associated with endothelial dysfunction. The present study was designed to investigate the correlation between the populations of circulating CD34-positive cells and endothelial progenitor cells and CSVD burden. Methodology & results: A total of 364 patients with confirmed diagnosis of CSVD were included in this prospective study. Multiple ordinal logistic regression analyses showed that subjects with higher CSVD burden had significantly decreased circulating CD34+ cell level (odds ratio [OR], 0.42; p = 0.034) and significantly increased levels of circulating CD34+CD133+CD309+ and CD34+CD133+ cells (OR 1.07, p = 0.031; OR 1.03, p = 0.001, respectively), compared with patients with lower CSVD burden. Conclusion: The findings suggest that the levels of circulating CD34+ cells, CD34+CD133+CD309+ cells and CD34+CD133+ cells may be used as potential biomarkers to monitor the disease progression of CSVD.
