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Polymorphonuclear leukocytes labeled with technetium-99m HMPAO. A potential bone marrow imaging agent.
J D Bennett1, R A Dubeau, A A Driedger
1Department of Nuclear Medicine, Victoria Hospital, London, Ontario, Canada.
Clinical Nuclear Medicine
|January 1, 1988
Summary
Multifocal avascular necrosis in systemic lupus erythematosus was identified using Tc-99m HMPAO leukocyte imaging. This technique shows promise for visualizing bone marrow involvement in such cases.
Area of Science:
- Nuclear medicine
- Rheumatology
- Bone pathology
Background:
- Systemic lupus erythematosus (SLE) can lead to avascular necrosis (AVN).
- Diagnosing multifocal AVN in SLE can be challenging.
- Standard imaging may not always reveal the full extent of bone involvement.
Observation:
- A case study involving a patient with SLE.
- The patient presented with multifocal avascular necrosis.
- Tc-99m HMPAO leukocyte imaging was utilized for assessment.
Findings:
- The extent of multifocal avascular necrosis was incidentally identified.
- Tc-99m HMPAO labeled leukocytes demonstrated effectiveness in imaging.
- This imaging modality highlighted bone marrow involvement.
Implications:
- Tc-99m HMPAO leukocyte imaging may serve as a valuable tool for bone marrow imaging.
- It could improve the diagnosis and management of AVN in SLE patients.
- Further research into this imaging agent for bone marrow assessment is warranted.