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Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy

Danielle P Johnson1, Mahesh B Chandrasekharan1, Marie Dutreix2

  • 1Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.

Cancers
|January 27, 2021
PubMed

Insights

Aberrant DNA repair pathways are key targets for treating developmental diseases and cancers. Research is advancing DNA repair therapeutics, exploring chromatin

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Aberrant DNA repair pathways are implicated in developmental diseases and cancers.
  • Targeting DNA repair mechanisms offers therapeutic potential.
  • Chromatin modulation is increasingly recognized as crucial in DNA repair.

Purpose of the Study:

  • To review advancements in DNA repair-based therapeutics.
  • To discuss the interplay between chromatin and DNA repair pathways.
  • To highlight the relevance in cancer treatment.

Main Methods:

  • Literature review of DNA repair mechanisms.
  • Analysis of chromatin's role in DNA repair.
  • Focus on therapeutic strategies and clinical translation.

Main Results:

  • Targeting DNA repair effectors, modulators, and checkpoint proteins has yielded significant discoveries.
  • Synthetic lethality approaches are proving effective.
  • The integration of chromatin modulation into DNA repair is a rapidly developing area.

Conclusions:

  • DNA repair pathways represent promising targets for novel cancer therapies.
  • Understanding chromatin dynamics is essential for developing effective DNA repair-based treatments.
  • Translating basic research into clinical applications for DNA repair therapeutics is ongoing.
Keywords:
DNA repaircancer therapyhistone deacetylasesrepair inhibition

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