Related Experiment Videos
Correlation between plasma and tonsillar levels of cefroxadine.
F Fraschini1, F Scaglione, F Vago
1Department of Pharmacology, University of Milan, Italy.
Chemotherapy
|January 1, 1988
Summary
Cefroxadine, a broad-spectrum cephalosporin, shows effective levels in tonsillar tissue, suggesting good penetration for treating ear, nose, and throat (ENT) infections.
Area of Science:
- Pharmacology
- Microbiology
- Otolaryngology
Background:
- Cefroxadine is a novel broad-spectrum cephalosporin antibiotic.
- This antibiotic has demonstrated efficacy in various infections, particularly those affecting the ear, nose, and throat (ENT).
Purpose of the Study:
- To measure serum and tonsillar tissue concentrations of cefroxadine.
- To evaluate the drug's penetration into tonsillar tissue in patients undergoing tonsillectomy.
- To correlate drug levels with potential clinical efficacy in ENT infections.
Main Methods:
- Twenty patients (11-25 years) received cefroxadine (500 mg every 12 h for 2 days, then 500 mg pre-surgery).
- Tonsillar tissue samples were collected 2 hours post-dose on the 3rd day.
- Blood samples were collected at multiple time points (pre-dose, 1, 2, 4, 6 hours) in 8 patients.
- Cefroxadine concentrations were determined using microbiological assays.
Main Results:
- Mean cefroxadine tonsillar tissue levels reached 1.13 +/- 1.73 micrograms/g.
- These levels approach the minimum inhibitory concentration (MIC) for susceptible bacteria.
- Plasma concentration-time profiles were consistent with previous studies.
- The drug demonstrated rapid penetration into tonsillar tissue.
Conclusions:
- Cefroxadine exhibits rapid penetration into tonsillar tissue.
- The measured tissue concentrations support the clinical effectiveness of cefroxadine in treating ENT infections.