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[Long-term course of chronic polyarthritis under basic drug therapy]
H Mattern1, U Leiendecker, T Krahe
1Medizinische Klinik Nord, Universität Bonn.
Deutsche Medizinische Wochenschrift (1946)
|March 25, 1988
Summary
Basic medications improved chronic rheumatoid arthritis (CRA) clinical symptoms but did not alter laboratory results or halt joint destruction. Long-term remission of inflammation was achieved, but not of progressive joint damage.
Area of Science:
- Rheumatology
- Immunology
- Pharmacology
Background:
- Chronic rheumatoid arthritis (CRA) is an autoimmune disease characterized by inflammation and joint destruction.
- Basic medications are used to manage CRA, but their long-term effects on disease progression are not fully understood.
Purpose of the Study:
- To evaluate the efficacy of basic medications in patients with chronic rheumatoid arthritis.
- To assess the impact of basic medications on clinical, biochemical, immunological, and radiological parameters of CRA.
Main Methods:
- Retrospective analysis of 31 patients with chronic rheumatoid arthritis (CRA).
- Patients were treated with basic medications including gold salts, D-penicillamine, chloroquine, or azathioprine.
- Disease activity was assessed using clinical, biochemical, immunological, and radiological criteria.
Main Results:
- Basic medications improved clinical symptoms of CRA but did not alter laboratory results.
- Immunological results showed a relationship with clinical and radiological findings.
- Functional index worsened despite clinical improvement, and joint destruction was higher in seropositive patients.
Conclusions:
- Basic medications can achieve long-term remission of inflammatory changes in CRA.
- These medications do not prevent the progression of joint destruction in chronic rheumatoid arthritis.
- Further research is needed to explore strategies for halting joint damage in CRA.