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microRNA-21: a key modulator in oncogenic viral infections

Guitian He1, Juntao Ding2, Yong'e Zhang1

  • 1State Key Laboratory of Veterinary Etiological Biology' and 'Key Laboratory of Veterinary Parasitology of Gansu Province, CAAS, Lanzhou, China.

RNA Biology
|January 27, 2021
PubMed

Insights

MicroRNAs, like miR-21, are crucial in viral infections and cancer development. Understanding miR-21

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Oncogenic viruses cause approximately 15% of human cancers.
  • MicroRNAs (miRNAs) are key regulators in host-pathogen interactions during viral infections.

Purpose of the Study:

  • To investigate the role of the microRNA miR-21 in viral infections and its implications for cancer development.
  • To explore how miR-21 influences host immune evasion and viral replication.

Main Methods:

  • Analysis of scientific literature on oncogenic viruses (HBV, HCV, HPV, EBV) and microRNA regulation.
  • Review of studies detailing miR-21's interaction with intracellular pathways and host immune responses.

Main Results:

  • miR-21 is upregulated in response to oncogenic viral infections.
  • Upregulated miR-21 manipulates cellular pathways to promote viral replication and evade immune detection.
  • miR-21 plays a significant role in the pathogenesis of virus-associated cancers.

Conclusions:

  • miR-21 is a critical factor in the interplay between oncogenic viruses and the host.
  • Targeting miR-21 could offer novel therapeutic strategies for virus-induced cancers.
  • Further research into miR-21's function may lead to advanced oncolytic virus-based cancer therapies.
Keywords:
Microrna-21ebvhbvhcvhivhpvoncolytic virus

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