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Acute Ischemic Stroke in a Young Patient with Left Ventricular Thrombus Attributed to Doxorubicin Cardiomyopathy

Eung-Joon Lee1, Byung-Woo Yoon1

  • 1Department of Neurology, Seoul National University Hospital, Seoul, Republic of Korea.

Case Reports in Neurology
|January 28, 2021
PubMed

Insights

We report a case of stroke caused by a left ventricular thrombus in a patient with doxorubicin-induced cardiomyopathy. This highlights a serious complication of doxorubicin cardiotoxicity.

Area of Science:

  • Cardiology
  • Neurology
  • Oncology

Background:

  • Doxorubicin is a common chemotherapy agent with known cardiotoxicity.
  • Doxorubicin cardiomyopathy can lead to decreased left ventricular contractility.
  • Left ventricular thrombus (LVT) formation is a potential complication of reduced cardiac function.

Observation:

  • A patient with doxorubicin cardiomyopathy developed an acute ischemic stroke.
  • Imaging revealed a left ventricular thrombus as the source of the embolism.
  • The stroke occurred in the middle cerebral artery territory.

Findings:

  • The left ventricular thrombus was identified as the cause of the middle cerebral artery ischemic infarction.
  • This case demonstrates a direct link between doxorubicin cardiomyopathy and embolic stroke.
  • Reduced ventricular contractility in doxorubicin cardiomyopathy predisposes to thrombus formation.

Implications:

  • Clinicians should be aware of the risk of stroke in patients with doxorubicin cardiomyopathy.
  • Echocardiography screening for LVT may be warranted in at-risk patients.
  • Understanding this complication can guide preventative strategies and patient management.

Keywords:
Brain infarctionCardiomyopathyDoxorubicinStrokeYoung adults

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