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Updated: Nov 19, 2025
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Published on: July 17, 2018
MiR-140-5p targets BCL2L1 to promote cardiomyocyte apoptosis
Abstract:
The article "MiR-140-5p targets BCL2L1 to promote cardiomyocyte apoptosis, by M.-Y. Sun, L.-P. Li, published in Eur Rev Med Pharmacol Sci 2020; 24 (11): 6311-6322-DOI: 10.26355/eurrev_202006_21529-PMID: 32572928" has been withdrawn from the authors. They stated that "they are still working on this study" and that "they found some current experimental results which are inconsistent with the previous ones. Moreover, they added that "these inconsistent results may be caused by the contamination of the previous experimental cell lines". The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/21529.
Insights
This study on microRNA-140-5p and BCL2L1 targeting cardiomyocyte apoptosis has been withdrawn due to inconsistent experimental results potentially caused by cell line contamination.
Area of Science:
- Cardiovascular Biology
- Molecular Biology
- Biomedical Research
Background:
- MicroRNAs (miRNAs) play crucial roles in regulating cellular processes.
- BCL2-like protein 1 (BCL2L1) is involved in apoptosis regulation.
Purpose of the Study:
- To investigate the role of microRNA-140-5p (miR-140-5p) in targeting BCL2L1.
- To elucidate the mechanism by which miR-140-5p promotes cardiomyocyte apoptosis.
Main Methods:
- The study involved molecular biology techniques to analyze gene and protein expression.
- Cellular assays were used to assess cardiomyocyte apoptosis.
Main Results:
- Initial findings suggested that miR-140-5p targets BCL2L1.
- The study indicated a role for miR-140-5p in promoting cardiomyocyte apoptosis.
Conclusions:
- The authors have withdrawn the study due to inconsistencies in experimental results.
- Potential cell line contamination is cited as a possible cause for the discrepancies.
