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Cell Adhesion in Plants01:14

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Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
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The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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Polymers02:34

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Polymeric Tissue Adhesives.

Sungmin Nam1,2, David Mooney1,2

  • 1John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02134, United States.

Chemical Reviews
|January 28, 2021
PubMed
Summary
This summary is machine-generated.

Polymeric tissue adhesives offer advantages over traditional wound closure methods. Future developments require understanding tissue-adhesive interactions for improved strength and function in wound care.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Surgical Innovation

Background:

  • Polymeric tissue adhesives are utilized for wound management across diverse medical scenarios, offering benefits over sutures and staples.
  • These adhesives provide rapid application, minimal tissue damage, hemostasis, and a conducive environment for tissue healing.
  • Current limitations include insufficient adhesion strength and suboptimal mechanical properties, necessitating further research and development.

Purpose of the Study:

  • To review the current state of polymeric tissue adhesives in wound management.
  • To outline rational design guidelines for next-generation tissue adhesives.
  • To discuss recent advancements, clinical considerations, and future potential of tissue adhesive technology.

Main Methods:

  • Literature review of polymeric tissue adhesives for wound closure.
  • Analysis of chemical and physical properties at the tissue-adhesive interface.
  • Evaluation of current commercial and developmental tissue adhesives.

Main Results:

  • Polymeric adhesives offer advantages in ease of use, speed, and reduced tissue trauma compared to traditional methods.
  • Adhesion strength and mechanical properties remain key challenges for current tissue adhesives.
  • A comprehensive understanding of interfacial mechanics and tissue-specific requirements is crucial for future innovation.

Conclusions:

  • Advancements in polymeric tissue adhesives hold significant promise for revolutionizing wound care.
  • Future adhesives require a deeper understanding of fundamental adhesion mechanisms and tailored properties for specific applications.
  • Next-generation adhesives could offer potent therapeutic solutions beyond simple wound closure.