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Related Concept Videos

Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Increased Body Temperature01:25

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Decreased Body Temperature01:29

Decreased Body Temperature

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A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
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Types of Fever01:25

Types of Fever

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Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
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Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
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Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

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Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
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Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
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Drug-induced Hyperthermic Syndromes in Psychiatry.

Stanley N Caroff1,2,3, Charles B Watson3, Henry Rosenberg3

  • 1Corporal Michael J. Crescenz VA Medical Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|January 28, 2021
PubMed
Summary

Drug-induced hyperthermia, a dangerous rise in body temperature, can occur from various medications and substances. Prompt recognition and management are crucial for preventing severe outcomes and mortality.

Keywords:
Antipsychotic agentsInduced hyperthermiaMalignant hyperthermiaNeuroleptic malignant syndromeSerotonin syndromeSubstance use disorders

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Area of Science:

  • Neuroscience
  • Toxicology
  • Pharmacology

Background:

  • Hyperthermia, or elevated body temperature, is a life-threatening condition.
  • It can be triggered by prescription drugs or illicit substances affecting the nervous system.
  • Certain psychotropic drug classes are linked to a syndrome of hyperthermia, muscle issues, and altered mental status.

Purpose of the Study:

  • To highlight the critical need for clinicians to recognize and manage drug-induced hyperthermia.
  • To discuss the clinical presentation and underlying mechanisms of these adverse effects.
  • To explore potential common pathways and genetic predispositions for these syndromes.

Main Methods:

  • Review of clinical syndromes associated with drug-induced hyperthermia.
  • Analysis of psychotropic drug classes and their impact on body temperature regulation.
  • Examination of theoretical mechanisms and genetic factors.

Main Results:

  • Drug-induced hyperthermia presents with a consistent clinical picture including hyperthermia, muscle rigidity, and altered mental status.
  • Despite similar presentations, the underlying mechanisms vary significantly between different drug classes.
  • Withdrawal of the offending agent and intensive care are primary management strategies.

Conclusions:

  • Clinicians must maintain a high index of suspicion for drug-induced hyperthermia.
  • Effective management requires prompt identification of triggering agents and supportive care.
  • Further research into common mechanisms, termed "thermic stress syndrome," may reveal shared predispositions.