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Updated: Nov 19, 2025
06:21
Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
Published on: May 10, 2024
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[Progress in conversion therapy for stage IV gastric cancer]
1Department of Gastric Surgery, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Centerfor Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China.
Summary
Advanced gastric cancer treatment is evolving. New chemotherapy regimens and targeted therapies, including immunotherapy, offer improved survival chances for stage IV patients, paving the way for personalized treatment strategies.
Area of Science:
- Oncology
- Gastroenterology
- Cancer Therapeutics
Background:
- Gastric cancer is a leading malignancy in China, frequently diagnosed at advanced stages.
- Current treatments for inoperable stage IV gastric cancer aim to reduce tumor burden and enable radical surgery.
- Past trials like REGATTA showed limited survival benefits from palliative surgery plus chemotherapy.
Purpose of the Study:
- To review advancements in conversion therapy for stage IV gastric cancer.
- To highlight novel chemotherapeutic and targeted drug combinations.
- To discuss the role of immunotherapy and future directions in personalized treatment.
Main Methods:
- Review of clinical trials and therapeutic strategies for stage IV gastric cancer.
- Analysis of neoadjuvant chemotherapy regimens, including intraperitoneal and intravenous approaches.
- Evaluation of targeted therapies (e.g., apatinib) and immunotherapy combinations.
Main Results:
- Neoadjuvant chemotherapy can downstage some stage IV gastric cancers, allowing for surgical intervention and improved survival.
- Paclitaxel-based regimens are effective in improving disease-free and overall survival, establishing them as a cornerstone of conversion therapy.
- Combination therapies, including targeted agents like apatinib and immunotherapy (anti-PD1), show promise for advanced gastric cancer, especially Her-2 positive cases.
Conclusions:
- Conversion therapy for stage IV gastric cancer has advanced significantly with new drug combinations.
- Individualized treatment plans, incorporating gene detection for classification, are crucial for optimizing long-term survival.
- The integration of chemotherapy, targeted therapy, and immunotherapy represents a new era in treating advanced gastric cancer.
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