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Updated: Nov 19, 2025
09:39
Real-Time Measurement of the Mitochondrial Bioenergetic Profile of Neutrophils
Published on: June 2, 2023
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Neutrophil dysfunction in bronchiectasis: an emerging role for immunometabolism
Yan Hui Giam1, Amelia Shoemark1, James D Chalmers2
1Division of Molecular and Clinical Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
The European Respiratory Journal
|January 29, 2021
Summary
Bronchiectasis involves neutrophil dysfunction, potentially reversed by targeting cell metabolism. Activating pathways like AMPK could enhance bacterial clearance and reduce disease severity.
Area of Science:
- Pulmonary Medicine
- Immunology
- Metabolic Research
Background:
- Bronchiectasis is a complex lung disease with poorly understood pathophysiology.
- Neutrophilic inflammation and impaired pathogen killing are central to bronchiectasis.
- Current therapies do not directly target neutrophilic inflammation in bronchiectasis.
Purpose of the Study:
- To review neutrophil dysfunction in bronchiectasis.
- To explore immunometabolic reprogramming as a cause of neutrophil dysfunction.
- To propose novel therapeutic strategies targeting neutrophil metabolism.
Main Methods:
- Review of current literature on bronchiectasis pathophysiology and neutrophil function.
- Analysis of evidence linking immunometabolic reprogramming to neutrophil dysfunction.
- Discussion of potential therapeutic targets, including AMPK activators.
Main Results:
- Neutrophil dysfunction in bronchiectasis aligns with immunometabolic reprogramming.
- Targeting neutrophil metabolism offers a novel therapeutic approach.
- AMPK activation demonstrates potential in reversing neutrophil dysfunction in pulmonary models.
Conclusions:
- Targeting neutrophil metabolism, rather than solely reducing inflammation, is a promising strategy for bronchiectasis.
- Immunomodulatory approaches enhancing bacterial clearance are needed.
- AMPK activators represent a potential therapeutic avenue for bronchiectasis.
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