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Multimodal Volumetric Retinal Imaging by Oblique Scanning Laser Ophthalmoscopy oSLO and Optical Coherence Tomography OCT
Published on: August 4, 2018
8.7K
Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz
Mehdi Azimipour1, Justin V Migacz1, Robert J Zawadzki1
1Vision Science and Advanced Retinal Imaging Laboratory (VSRI), Department of Ophthalmology and Vision Science, UC Davis Eye Center, Sacramento, California 95817, USA.
Optica
|January 29, 2021
Summary
This study introduces an adaptive optics optical coherence tomography system to measure single cone photoreceptor responses. This novel method detects functional changes, potentially enabling earlier diagnosis of retinal diseases.
Area of Science:
- Ophthalmology
- Biomedical Optics
- Retinal Imaging
Background:
- Current methods for retinal disease diagnosis have limitations in early detection.
- Optical assessment of photoreceptor function offers potential for earlier diagnosis.
Purpose of the Study:
- To develop and describe an adaptive optics optical coherence tomography (AO-OCT) system.
- To measure functional responses of single cone photoreceptors to visible stimuli.
Main Methods:
- Utilized a raster-scanning Fourier-domain mode-locked laser OCT system (1.64 MHz, 1063 nm center wavelength).
- Integrated a closed-loop adaptive optics (AO) system for high-resolution imaging.
- Analyzed serial volumetric images to assess cone photoreceptor changes.
Main Results:
- Observed phase changes in cone photoreceptors correlated with outer segment elongation.
- Demonstrated that elongation was proportional to stimulus intensity.
- Identified other morphological changes in the outer segment and retinal pigment epithelium.
Conclusions:
- AO-OCT can measure functional responses of individual cone photoreceptors.
- Detected stimulus-induced changes in cone morphology, indicating functional assessment.
- This technology may lead to earlier detection of retinal diseases.
