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The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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Updated: Nov 19, 2025

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

Immune response in glioma's microenvironment.

Houminji Chen^1,2, Ming Li³, Yanwu Guo¹

¹The Second School of Clinical Medicine, Southern Medical University, Guangzhou, P. R. China.

Innovative Surgical Sciences

|January 29, 2021

Summary

This summary is machine-generated.

This review explores glioma's tumor microenvironment (TME) and its immunobiological factors. Understanding these interactions offers new targets for inhibiting glioma development and improving brain tumor treatments.

Keywords:

cytokines glioma immunoregulatory factors macrophages microglia myeloid-derived suppressor cells tumor microenvironment

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Area of Science:

Neuro-oncology
Immunology
Cancer Biology

Background:

Glioma cells interact with the tumor microenvironment (TME), involving immune cells like microglia, macrophages, myeloid-derived suppressor cells (MDSCs), and T lymphocytes.
Microglia are particularly significant in promoting glioma growth, while infiltrating immune cells contribute to immune escape through cytokine and chemokine production.
Tumor cell interactions within the TME drive glioma heterogeneity and poor patient prognosis.

Purpose of the Study:

To review the immunobiological factors influencing glioma development.
To identify potential therapeutic targets within the glioma TME.
To provide insights into future research and treatment strategies for gliomas.

Main Methods:

Comprehensive literature review of immunobiological factors in glioma.
Analysis of immune cell interactions within the glioma TME.
Examination of current glioma immunotherapy approaches.

Main Results:

Identification of key immunobiological factors and immune cells mediating glioma progression.
Elucidation of mechanisms contributing to immune evasion in malignant gliomas.
Highlighting the role of TME complexity in tumor heterogeneity.

Conclusions:

Understanding glioma-TME interactions is crucial for developing novel therapeutic strategies.
Targeting specific immunobiological factors and immune cells presents promising avenues for glioma treatment.
Further research into these interactions will advance brain tumor immunotherapy.