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Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.
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Allosteric proteins have more than one ligand binding site; the binding of a ligand to any of these sites influences the binding of ligands to the other sites. When a protein is allosteric, its binding sites are called coupled or linked.  In the case of enzymes, the site that binds to the substrate is known as the active site and the other site is known as the regulatory site. When a ligand binds to the regulatory site, this leads to conformational changes in the protein that can influence...
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Metal-Organic Cages with Missing Linker Defects.

Xianhui Tang1, Dandan Chu1, Wei Gong1

  • 1School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240, China.

Angewandte Chemie (International Ed. in English)
|January 29, 2021
PubMed
Summary
This summary is machine-generated.

Controlled synthesis of defective coordination cages was achieved using steric hindrance in organic linkers. These cages exhibit adaptable cavities for accommodating guest molecules, offering new possibilities in materials science.

Keywords:
defective assemblieshost-guestmetal-organic cageself-assemblysupramolecular chemistry

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Area of Science:

  • Supramolecular Chemistry
  • Coordination Chemistry
  • Materials Science

Background:

  • Coordination cages are versatile supramolecular structures with applications in host-guest chemistry and catalysis.
  • Controlling the defectiveness of coordination cages is crucial for tuning their properties and functionalities.
  • Steric hindrance in organic linkers offers a potential strategy for manipulating cage assembly and defect formation.

Purpose of the Study:

  • To demonstrate the controlled synthesis of defective coordination cages by utilizing steric hindrance of organic linkers.
  • To investigate the effect of varying steric hindrance on the coordination modes and resulting cage structures.
  • To explore the host-guest properties of the synthesized defective coordination cages.

Main Methods:

  • Design and synthesis of three chiral 1,1'-bi-2-naphthol (BINOL) derived bis-tridentate ligands (L1-L3) with pyridine-2,6-dicarboxamide (pcam) chelating moieties.
  • Complexation of these ligands with lanthanides to form coordination cages.
  • Structural characterization of the resulting coordination cages using X-ray crystallography.
  • Analysis of the defectiveness and cavity adaptability of the synthesized cages.

Main Results:

  • Synthesis of irregular Ln8(L1)10 hexahedra (two missing edges) and Ln4(L2)5 tetrahedra (one missing edge) with L1 and L2, respectively, showing a 1:1 mixture of Ln(pcam)2 and Ln(pcam)3 vertices.
  • Formation of regular twisted Ln6(L3)9 trigonal prisms (no missing edges) with L3, exclusively containing Ln(pcam)3 vertices.
  • Demonstration that smaller steric hindrance in L3 leads to regular, non-defective cages, while larger hindrance in L1 and L2 results in defective cages.
  • Defective cages exhibit structural flexibility and adaptable cavities for guest molecule encapsulation.

Conclusions:

  • Steric hindrance of organic linkers is an effective strategy for controlling the defectiveness of coordination cages.
  • Defective coordination cages possess tunable structural conformations and adaptable cavities.
  • The ability to control defect formation opens avenues for designing advanced host-guest materials with tailored encapsulation properties.