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circFOXO3: Going around the mechanistic networks in cancer by interfering with miRNAs regulatory networks

Rares Drula1, Radu Pirlog1, Monica Trif2

  • 1Research Center for Functional Genomics Biomedicine and Translational Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|January 29, 2021
PubMed

Insights

Circular RNAs (circRNAs) are versatile regulators in disease. CircFOXO3 shows significant implications in cancer, highlighting its potential as a biomarker and therapeutic target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are emerging as key regulators in complex biological networks.
  • Their interactions with RNA and proteins are crucial in pathogenic mechanisms.
  • CircFOXO3, derived from FOXO3 mRNA, is a notable circRNA with implications in cancer.

Purpose of the Study:

  • To investigate the role and implications of CircFOXO3 in various cancers.
  • To focus on CircFOXO3-miRNA-mRNA regulatory networks and protein interactions.
  • To explore the biomarker and therapeutic potential of CircFOXO3 in cancer.

Main Methods:

  • Review of current literature on CircFOXO3 in cancer.
  • Analysis of CircFOXO3's interactions with microRNAs (miRNAs) and messenger RNAs (mRNAs).
  • Examination of CircFOXO3's protein-binding partners and their functional consequences.

Main Results:

  • CircFOXO3 plays a significant role in key tumorigenesis mechanisms.
  • Specific CircFOXO3-miRNA-mRNA networks are implicated in cancer development.
  • CircFOXO3 interacts with various proteins, influencing tumor progression.

Conclusions:

  • CircFOXO3 has a multifaceted role in cancer, impacting multiple regulatory pathways.
  • Understanding CircFOXO3's mechanisms offers insights into cancer biology.
  • CircFOXO3 presents promising potential as a diagnostic biomarker and therapeutic agent for cancer.
Keywords:
FOXO3Regulatory networkscircFOXO3circRNAmiRNA

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