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Updated: Nov 19, 2025
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Conjunctival Commensal Isolation and Identification in Mice
Published on: May 1, 2021
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Current Evidence for Corynebacterium on the Ocular Surface
Takanori Aoki1, Koji Kitazawa1, Hideto Deguchi1
1Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.
Microorganisms
|January 30, 2021
Summary
Corynebacterium bacteria, often harmless on the eye, can cause infections in immunocompromised patients. Third-generation cephems are effective against these ocular infections, showing consistent susceptibility.
Area of Science:
- Ophthalmology
- Microbiology
- Infectious Diseases
Background:
- Corynebacterium species are common, typically non-pathogenic inhabitants of the human conjunctiva.
- Recent reports indicate potential pathogenicity of Corynebacterium in various tissues, including the eye.
Purpose of the Study:
- To investigate Corynebacterium species on the ocular surface.
- To review antimicrobial susceptibility and molecular resistance mechanisms of ocular Corynebacterium.
Main Methods:
- Literature review of Corynebacterium species, antimicrobial susceptibility, and resistance mechanisms.
- Identification of risk factors for Corynebacterium-related ocular infections.
Main Results:
- Identified risk factors including poor immunity (diabetes, topical steroid use) and corneal damage (trauma, contact lens wear).
- C. macginleyi was the predominant conjunctival strain; several species were linked to keratitis and conjunctivitis.
- Ocular Corynebacterium showed quinolone resistance, unlike more susceptible nasal strains. Fluoroquinolone resistance remained stable, but susceptibility to third-generation cephems persisted.
Conclusions:
- Third-generation cephems represent a rational and practical treatment choice for ocular infections caused by Corynebacterium species.
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