Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Viruses with RNA Genomes01:29

Viruses with RNA Genomes

397
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
397
Size and Structure of Viral Genomes01:26

Size and Structure of Viral Genomes

406
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
406
Sanger Sequencing01:57

Sanger Sequencing

766.9K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
766.9K
Viral Recombination00:57

Viral Recombination

24.4K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
24.4K
Viral Mutations00:36

Viral Mutations

37.5K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
37.5K
Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

307
Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
307

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Shotgun metagenomic profiling reveals ecological and functional alterations of the oral microbiome in craniosynostosis.

Journal of oral microbiology·2026
Same author

Interpretable graph-based models on multimodal biomedical data integration: a technical review and benchmarking.

Nature communications·2026
Same author

Predicting Fall Risk in Community-Dwelling Older Adults Using a Fine-Tuned Quantized Large Language Model.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2026
Same author

Comprehensive evaluation of ACMG/AMP-based variant classification tools.

Bioinformatics (Oxford, England)·2026
Same author

LRP6 β-Propeller Destabilization: Novel Variant, Phenotype and Diagnostic Implications in Tooth Agenesis.

International dental journal·2026
Same author

Hybrid attention based deep learning for forecasting boundary layer ozone using satellite derived profiles.

Ecotoxicology and environmental safety·2025
Same journal

Tissue MicroRNAs in Arrhythmogenic Cardiomyopathy: A Systematic Review of Studies in Human Myocardium and Animal Models with Implications for Post-Mortem Molecular Diagnostics.

Genes·2026
Same journal

Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.

Genes·2026
Same journal

Generative AI and Language Models in Human Genetics and Health: From Variant Interpretation to Clinical Decision Support.

Genes·2026
Same journal

Familial White-Sutton Syndrome Caused by a Pathogenic POGZ p.Arg508* Variant: Intrafamilial Variability from Childhood to Adulthood.

Genes·2026
Same journal

Genetic Influence on LDL-Cholesterol Levels: Role of Polygenic Risk Scores and Lp(a) Beyond Monogenic Hypercholesterolemia.

Genes·2026
Same journal

THBS1 as a Key Regulator of Myoblasts: Validation of Its Inhibitory Roles in Skeletal Muscle Development.

Genes·2026
See all related articles

Related Experiment Video

Updated: Nov 19, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.5K

VIRMOTIF: A User-Friendly Tool for Viral Sequence Analysis.

Pedram Rajaei1, Khadijeh Hoda Jahanian2, Amin Beheshti3

  • 1Amirkabir University of Technology, Tehran 346512, Iran.

Genes
|January 30, 2021
PubMed
Summary
This summary is machine-generated.

VIRMOTIF is a new bioinformatics tool that analyzes DNA sequences, offering motif analysis, data visualization, and clustering. It uniquely analyzes viral genomic motifs by frequency and representation (D-ratio).

Keywords:
D-ratiomotif analysissequence analysissequence variationvirus genome

More Related Videos

Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis
10:33

Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis

Published on: June 17, 2019

11.1K
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.3K

Related Experiment Videos

Last Updated: Nov 19, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.5K
Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis
10:33

Multi-locus Variable-number Tandem-repeat Analysis of the Fish-pathogenic Bacterium Yersinia ruckeri by Multiplex PCR and Capillary Electrophoresis

Published on: June 17, 2019

11.1K
Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'
08:31

Isolation and Genome Analysis of Single Virions using 'Single Virus Genomics'

Published on: May 26, 2013

11.3K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Bioinformatics and computational biology have advanced biological research.
  • Numerous tools exist, but a comprehensive, user-friendly package for DNA sequence analysis is needed.

Purpose of the Study:

  • To introduce VIRMOTIF, a novel, user-friendly bioinformatics tool for comprehensive DNA sequence analysis.
  • To integrate diverse analytical functions into a single, accessible package.

Main Methods:

  • VIRMOTIF computes motif occurrences and probabilities in DNA sequences.
  • It incorporates data visualization using matplotlib and heatmap libraries.
  • Includes data clustering via K-means, PCA, Mean Shift, and ClusterMap algorithms.

Main Results:

  • VIRMOTIF provides a unified platform for multiple DNA sequence analysis tasks.
  • It uniquely analyzes viral genomic motifs using frequency and D-ratio.
  • Facilitates data visualization and clustering for enhanced biological insights.

Conclusions:

  • VIRMOTIF offers a comprehensive and user-friendly solution for DNA sequence analysis.
  • Its unique D-ratio analysis for viral motifs advances genomic research.
  • The integrated approach enhances efficiency and accessibility for researchers.