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Left and right ventricular dysfunction in patients with COVID-19-associated myocardial injury

Stéphanie Bieber1,2, Angelina Kraechan3,4, Johannes C Hellmuth4,5

  • 1Medizinische Klinik und Poliklinik I, Klinikum der Universitaet Muenchen, Ludwig-Maximilians-University, Marchioninistraße 15, 81377, Munich, Germany. Stephanie.Bieber@med.uni-muenchen.de.

Infection
|January 30, 2021
PubMed

Insights

COVID-19 can cause heart muscle injury, leading to ventricular dysfunction. Echocardiography revealed impaired left and right ventricular function in patients with myocardial injury, which showed partial recovery over time.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Imaging

Background:

  • COVID-19, caused by SARS-COV-2, is a multi-organ disease.
  • Myocardial injury is a known complication, but its echocardiographic characteristics are not fully understood.

Purpose of the Study:

  • To characterize echocardiographic patterns of ventricular function in patients with COVID-19-associated myocardial injury.

Main Methods:

  • Prospective assessment of 32 hospitalized COVID-19 patients using comprehensive 3D and strain echocardiography.
  • Patients were categorized based on elevated high-sensitivity troponin T (hsTNT+ vs. hsTNT-).

Main Results:

  • 65.7% of patients exhibited left and/or right ventricular dysfunction.
  • hsTNT+ patients commonly showed biventricular dysfunction, impaired left ventricular global longitudinal strain (GLS), and reduced right ventricular (RV) systolic function.
  • Myocardial dysfunction partially recovered in hsTNT+ patients after 52 days.

Conclusions:

  • COVID-19-associated myocardial injury is linked to left and right ventricular dysfunction.
  • Echocardiography, particularly 3D and strain imaging, effectively revealed these dysfunctions.
  • Ventricular dysfunction showed partial resolution at a 2-month follow-up.
Abstract

Keywords:
COVID-19Global longitudinal strainHeart failureMyocardial injuryThree-dimensional echocardiography

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