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Updated: Nov 19, 2025

Femtosecond Laser Filaments for Use in Sub-Diffraction-Limited Imaging and Remote Sensing
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Femtosecond Lasers in Cornea & Refractive Surgery.

Kareem Sioufi1, Len Zheleznyak2, Scott MacRae3

  • 1Storm Eye Institute, Medical University of South Carolina, Charleston, SC, USA.

Experimental Eye Research
|January 31, 2021
PubMed
Summary
This summary is machine-generated.

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Femtosecond lasers offer diverse applications in corneal surgery, from refractive procedures and keratoplasty to diagnostic imaging. These advanced laser systems enhance precision and outcomes in various ophthalmic interventions.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Laser Surgery

Background:

  • Femtosecond laser (FS) systems have revolutionized corneal flap creation in laser-assisted in-situ keratomileusis.
  • The versatility of FS laser technology has led to its adoption in a wide range of ophthalmic procedures.

Purpose of the Study:

  • To detail the extensive utility of femtosecond lasers in various corneal surgical procedures.
  • To review the application of FS lasers in both therapeutic and diagnostic ophthalmic interventions.

Main Methods:

  • Review of current literature and clinical applications of femtosecond lasers in corneal surgery.
  • Analysis of FS laser use in refractive surgeries, intracorneal ring segment tunnels, presbyopic treatments, and keratoplasty.
  • Examination of FS laser roles in diagnostic techniques like two-photon excitation fluorescence and second harmonic generation.
Keywords:
CorneaFASKFLAKFLExFemtosecondICRSINTRACORISAKKeratoplastyLASIKLIRIKLaserNLOPresbyopiaRefractive surgerySHGSMILETPEF

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Main Results:

  • Femtosecond lasers are integral to modern refractive laser surgeries, offering precise flap creation and stromal ablation.
  • Applications extend to creating intracorneal ring segment tunnels for keratoconus and precise incisions for FS-assisted keratoplasty.
  • FS lasers are employed in advanced diagnostic imaging, providing detailed visualization of corneal structures.

Conclusions:

  • Femtosecond laser technology has significantly expanded the scope and precision of corneal surgical procedures.
  • The utility of FS lasers spans refractive correction, therapeutic interventions, and sophisticated diagnostic capabilities in ophthalmology.
  • Continued innovation in FS laser applications promises further advancements in corneal surgery and diagnostics.