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Related Experiment Video

Updated: Nov 19, 2025

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The aging mouse brain: cognition, connectivity and calcium.

Carola I Radulescu1, Veronika Cerar1, Peter Haslehurst2

  • 1UK Dementia Research Institute, Department of Brain Sciences, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

Cell Calcium
|January 31, 2021
PubMed
Summary

Aging impacts mouse brain function, affecting cognition and senses early. Some neural processes show resilience, indicating varied age-related changes. Understanding these differences aids brain rejuvenation strategies.

Keywords:
AgingAxonal boutonCalciumCognitionCortexDendritic spineHebbian plasticityHippocampusHomeostatic plasticityIn vivo imagingLTDLTPNeural-circuitPlasticity

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Area of Science:

  • Neuroscience
  • Aging Research
  • Systems Biology

Background:

  • Aging affects cognitive, sensory, neuronal, and molecular functions.
  • Technological advances enable detailed study of the aging mouse brain.
  • A systems-based approach is needed to understand age-related neural processing changes.

Purpose of the Study:

  • To review evidence on how aging impacts the mouse brain.
  • To focus on neuronal function, cognitive abilities, sensory systems, synaptic plasticity, and calcium regulation.
  • To identify early age-related dysregulation and system resilience.

Main Methods:

  • Review of existing scientific literature.
  • Analysis of studies investigating age-related changes in mouse brain function.
  • Focus on cognitive, sensory, synaptic, and molecular processes.

Main Results:

  • Significant age-related dysregulation observed in many systems before 12 months of age.
  • Emerging age-related alterations manifest in late adulthood.
  • Certain neural processes demonstrate remarkable resilience to aging.

Conclusions:

  • Aging does not uniformly impact all neural systems linearly.
  • Some processes are affected earlier and more severely than others.
  • Identifying fine-scale age-related vulnerabilities and resilience is key for brain rejuvenation.