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Incidence of COVID-19 in patients under chronic treatment with hydroxychloroquine

Francisco Tejada Cifuentes1, Ángeles Lloret Callejo1, María José Tirado Peláez1

  • 1Gerencia de Atención Integrada de Albacete, Albacete, Spain.

Medicina Clinica (English Ed.)
|February 1, 2021
PubMed

Insights

Chronic hydroxychloroquine use did not increase Covid-19 incidence in a large observational study. The study found no link between hydroxychloroquine and Covid-19 infection rates.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Epidemiology

Background:

  • Hydroxychloroquine has been investigated for potential therapeutic roles in viral infections.
  • Understanding the impact of chronic medication use on infectious disease incidence is crucial for patient management.

Purpose of the Study:

  • To investigate the incidence of Coronavirus Disease 2019 (Covid-19) among individuals with a history of chronic hydroxychloroquine use.

Main Methods:

  • A cross-sectional, retrospective, observational, multicenter study was conducted.
  • Data from 3817 participants with valid records were analyzed.
  • Covid-19 infection was determined through clinical, serological, or polymerase chain reaction (PCR) diagnosis.

Main Results:

  • The overall incidence of Covid-19 was 4.45% (169 cases).
  • Of those infected, 7.1% died and 18.9% required hospitalization.
  • Pre-existing respiratory conditions were associated with increased Covid-19 incidence (P < .05).
  • Maculopathy occurred in 5.3% of patients, correlating significantly with hydroxychloroquine dosage (P < .05).

Conclusions:

  • This study found no statistically significant relationship between the chronic use of hydroxychloroquine and the incidence of Covid-19.
Abstract

Keywords:
COVID-19CoronavirusHydroxychloroquineIncidenceTreatment

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