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Updated: Nov 19, 2025
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Fluorescence Lifetime Imaging of Molecular Rotors in Living Cells
Published on: February 9, 2012
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Acridinium benzoates for ratiometric fluorescence imaging of cellular viscosity
Min Wen1, Chen Li, Mengyuan Zhang
1Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P.R. China. xycui@chem.ecnu.edu.cn.
The Analyst
|February 1, 2021
Abstract:
A series of fluorescent molecular rotors, acridinium benzoates (Acr-A,B,C,D), were designed for ratiometrically monitoring cellular viscosity. High sensitivity to viscosity was observed in probe Acr-A with an insignificant steric effect in the acridinium nitrogen. Acr-A was employed to distinguish cancer cells from normal cells and track the dynamics of viscosity during cellular apoptosis.
