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Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

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High-strength and fibrous capsule-resistant zwitterionic elastomers.

Dianyu Dong^1,2, Caroline Tsao¹, Hsiang-Chieh Hung¹

¹Department of Chemical Engineering, University of Washington, Seattle, WA 98185, USA.

Science Advances

|February 1, 2021

Summary

Researchers developed novel zwitterionic-elastomeric-networked (ZEN) hydrogels that overcome the trade-off between mechanical strength and resistance to fibrous capsule formation for implantable biomaterials.

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Area of Science:

Biomaterials Science
Polymer Chemistry
Implantable Device Technology

Background:

Implantable materials face challenges with mechanical strength and fibrous capsule formation, often compromising each other.
Achieving both high mechanical properties and long-term resistance to fibrous encapsulation remains a significant hurdle in biomaterial development.

Purpose of the Study:

To develop a novel class of zwitterionic hydrogels with integrated high mechanical strength and long-term resistance to fibrous capsule formation.
To provide new design principles for advanced zwitterionic elastomeric hydrogels for biomedical applications.

Main Methods:

Integration of two weak zwitterionic hydrogels into a pure zwitterionic hydrogel matrix using a "swelling" and "locking" mechanism.
Fabrication of zwitterionic-elastomeric-networked (ZEN) hydrogels.
In vivo implantation studies in mice for up to 1 year to evaluate fibrous capsule formation.

Main Results:

The developed ZEN hydrogels exhibit both high mechanical strength and excellent resistance to fibrous capsule formation.
Long-term implantation (up to 1 year) in mice demonstrated effective prevention of fibrous capsule formation.
This represents a breakthrough in achieving durable and biocompatible implantable materials.

Conclusions:

ZEN hydrogels offer a unique solution to the long-standing challenge of balancing mechanical integrity and biocompatibility in implantable materials.
The "swelling" and "locking" mechanism provides a viable strategy for designing advanced zwitterionic elastomeric hydrogels.
These findings pave the way for next-generation implantable devices with enhanced longevity and performance.