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Updated: Nov 19, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Nurse practitioners as antibiotic stewards: Examining prescribing patterns and perceptions.
Mary Jo Knobloch1, Jackson Musuuza1, Kelsey Baubie1
1William S. Middleton Memorial Veterans Hospital, Madison, WI; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
Advanced practice providers, including nurse practitioners (NPs), are crucial for antibiotic stewardship. Patient trust and education are key, and further research is needed to optimize stewardship strategies.
Area of Science:
- Healthcare Management
- Infectious Diseases
- Patient Safety
Background:
- Advanced practice providers (APPs) in outpatient settings are vital for antibiotic stewardship.
- Limited understanding exists regarding APP engagement in stewardship and factors influencing prescribing.
Purpose of the Study:
- To explore antibiotic prescribing practices and perceptions among outpatient nurse practitioners (NPs) and Veteran patients.
- To identify factors influencing NP antibiotic prescribing and inform outpatient antibiotic stewardship strategies.
Main Methods:
- Mixed-methods approach combining interviews with NPs and focus groups with Veteran patients.
- Analysis of NP antibiotic prescribing data from 2017-2019.
- Thematic analysis mapped to the Systems Engineering Initiative for Patient Safety framework.
Main Results:
- NPs reported satisfaction with access to pharmacists and infectious disease specialists.
- Patient trust was essential for NP prescribing confidence; Veterans desired better understanding of infection types.
- A decline in antibiotic prescriptions for upper respiratory illnesses by NPs was observed over three years.
Conclusions:
- Outpatient NPs balance patient education with organizational access challenges.
- Further research is necessary to integrate NPs and patients into outpatient antibiotic stewardship.
- Investigating factors behind the observed decline in NP antibiotic prescribing is warranted.
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