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Updated: Nov 19, 2025

Assaying Protein Kinase Activity with Radiolabeled ATP
Published on: May 26, 2017
Current status and future prospects of p38α/MAPK14 kinase and its inhibitors
Moustafa M Madkour1, Hanan S Anbar2, Mohammed I El-Gamal3
1College of Pharmacy, University of Sharjah, Sharjah, 27272, United Arab Emirates.
Abstract:
P38α (which is also named MAPK14) plays a pivotal role in initiating different disease states such as inflammatory disorders, neurodegenerative diseases, cardiovascular cases, and cancer. Inhibitors of p38α can be utilized for treatment of these diseases. In this article, we reviewed the structural and biological characteristics of p38α, its relationship to the fore-mentioned disease states, as well as the recently reported inhibitors and classified them according to their chemical structures. We focused on the articles published in the literature during the last decade (2011-2020).
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