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Bilateral dysthyroid compressive optic neuropathy responsive to teprotumumab
Catherine J Hwang1, Erin E Nichols1, Brian H Chon1
1Cleveland Clinic Foundation, Cole Eye Institute, Cleveland, OH, USA.
European Journal of Ophthalmology
|February 2, 2021
Summary
Teprotumumab, an IGF-IR inhibitor, effectively reversed vision loss from dysthyroid compressive optic neuropathy in thyroid eye disease. This offers a new medical management option for this condition.
Area of Science:
- Ophthalmology
- Endocrinology
- Immunology
Background:
- Thyroid eye disease is an autoimmune condition affecting the orbit.
- It can lead to dysthyroid compressive optic neuropathy, impairing vision.
- Current treatments like steroids, radiation, and surgery have limitations.
Purpose of the Study:
- To evaluate the efficacy of teprotumumab in medically managing dysthyroid compressive optic neuropathy.
- To report on the reversal of vision loss using teprotumumab.
Main Methods:
- The study involved patients with active thyroid eye disease and compressive optic neuropathy.
- Medical management with teprotumumab was utilized.
- Outcomes included reversal of optic neuropathy.
Main Results:
- Teprotumumab treatment led to the reversal of bilateral dysthyroid compressive optic neuropathy.
- This indicates a positive response to medical intervention.
Conclusions:
- Teprotumumab is a promising medical treatment for dysthyroid compressive optic neuropathy.
- It offers an alternative to traditional, more invasive therapies.
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