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Metronidazole-induced reversible cerebellar dysfunction.

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Summary
This summary is machine-generated.

Metronidazole, an antibiotic for liver abscess, can cause rare cerebellar neurotoxicity. Symptoms resolved after discontinuing the drug, highlighting the importance of considering this adverse effect.

Keywords:
drugs: CNS (not psychiatric)neuroimagingunwanted effects / adverse reactions

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Radiology

Background:

  • Liver abscesses are serious infections requiring antimicrobial therapy.
  • Metronidazole is a common antibiotic used to treat anaerobic bacterial infections, including liver abscesses.

Observation:

  • A 73-year-old male with a liver abscess developed cerebellar signs and symptoms after one month of metronidazole treatment.
  • Brain MRI revealed characteristic hyperintensities in the cerebellar nuclei.

Findings:

  • Metronidazole-induced neurotoxicity was diagnosed after excluding other causes.
  • Cessation of metronidazole led to complete resolution of neurological deficits.
  • Follow-up MRI confirmed the reversal of cerebellar changes.

Implications:

  • Metronidazole neurotoxicity is an uncommon but reversible adverse effect.
  • Clinicians should consider metronidazole-induced neurotoxicity in patients with cerebellar symptoms during treatment.
  • Early recognition and drug discontinuation can prevent long-term neurological damage.