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Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres
Bin Wang1, Rizhao Pan1, Weiping Zhu1
1Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China. triyang@ecust.edu.cn.
Soft Matter
|February 2, 2021
Abstract:
A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.
